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In itself I dont think vildagliptin is a very potent blood sugar reducing medicine.
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Enhanced insulin secretion causes increased uptake of glucose in the muscle and adipocyte and reduced outpouring of glucose from the liver.
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FS, MA, ER, FdP, and BB, and have no financial relationships with any organisations that might have an interest in the submitted work in the previous three years.
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Novartis and the FDA have been engaged in talks about what kind of data is needed to get an approval, but Vasella made it clear in a chat with analysts that no new trial will be mounted until the company gets a clear understanding of what the regulators are looking for.
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Your doctor may occasionally change your dose to make sure you get the best results.
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, non-inferiority trial.
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It is currently approved for use in treatment of T2DM in the European Union, Latin America (Brazil, Mexico), and Asia (Korea, Singapore, Philippines).
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The drug profile makes it a first line choice when thinking of a tool to increase beta-cell insulin secretion.
Baron joined Intarcia in March 2012 as Vice President, Clinical Research and Chief Medical Officer.
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The PBAC considered the submission's base case cost-minimisation analysis which assumed 50 % of vildagliptin would be used with metformin and 50 % with a sulfonylurea to be highly uncertain.
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The CHMP also noted that the combination of vildagliptin and metformin was effective as an add-on to a sulphonylurea or insulin.
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In patients with malabsorption even high dosage up to 180 mg per day would be ineffective.
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